PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S Blockade of TGF-β signaling by

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

(2008) Oncogene

Su-11274 induces G1 cell cycle arrest with cells in G1 phase increased from 42

CAS Number: 145821-59-6

Siddiqui-Jain A

PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S Blockade of TGF-β signaling byPFI 1, CAS No. 1403764 72 6, is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2 and BRD4 with IC50 of ~98 nM and 220 nM respectively. Co crystal structures showed that PFI 1 acts as an acetyl lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD2 and BRD4. It has an EC50 of 1. 89 M for the inhibition of IL6 production from human blood mononuclear cells