DAPT - γ-secretase Inhibitor. CAS# 208255-80-5 Catalog No.:M60023-10S InChi: InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H

InChi: InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H

(2011) Mol Oncol

353(Pt 2):333-8

which can be used to investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia

Formula: C17H15NO3

DAPT - γ-secretase Inhibitor. CAS# 208255-80-5 Catalog No.:M60023-10S InChi: InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10HDAPT, CAS No. 208255 80 5, is a widely used secretase inhibitor and serves as an inhibitor of Notch, a secretase substrate. It can also cause a reduction in A40 and A42 levels in human primary neuronal cells (IC50 ~115 nM for total A and ~200 nM for A42) and in brain extracts, as well as in vivo. Since the Notch pathway is involved in development of many cell types, DAPT is used to modulate Notch activity in ESC iPSC or adult stem cell differentiation